NOCIt – a computational tool to infer the number of contributors to a forensic DNA sample

نویسندگان

  • Harish Swaminathan
  • Catherine M. Grgicak
  • Muriel Medard
  • Desmond S. Lun
چکیده

1 Center for Computational and Integrative Biology, Rutgers University, Camden, NJ 08102, USA 2 Biomedical Forensic Sciences Program, Boston University School of Medicine, Boston, MA 02118, USA 3 Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 4 School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia *Corresponding author. Tel.: +1-856-225-6094. E-mail: [email protected]

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Application of Palatal Rugae for Sex Discrimination in Forensic Medicine in a Selected Iranian Population

Background: Palatal rugae have been shown to be associated with racial and geographical variations and are known to be useful in sex identification. The present study aimed to assess palatal rugae patterns in a sample Iranian population and to compare the results with those from other studied populations.Methods: During summer 2017, 130 pre-orthodontic plaster casts from patients aged 17-25 yea...

متن کامل

Resolution of mixed human DNA samples using mitochondrial DNA sequence variants.

Forensic casework samples routinely contain DNA from multiple contributors [1], posing a challenge to investigators attempting to resolve the components of complex DNA mixtures. Analysis of human mitochondrial DNA (mtDNA) is commonly used in forensic investigations to match evidentiary samples to potential suspects [2,3]. Unique DNA sequences from the hypervariable sequence (HVS) region of the ...

متن کامل

Interpreting DNA mixtures in structured populations.

DNA profiles from multiple-contributor samples are interpreted by comparing the probabilities of the profiles under alternative propositions. The propositions may specify some known contributors to the sample and may also specify a number of unknown contributors. The probability of the alleles carried by the set of people, known or unknown, depends on the allelic frequencies and also upon any r...

متن کامل

Complex mixtures: a critical examination of a paper by Homer et al.

DNA evidence in criminal cases may be challenging to interpret if several individuals have contributed to a DNA-mixture. The genetic markers conventionally used for forensic applications may be insufficient to resolve cases where there is a small fraction of DNA (say less than 10%) from some contributors or where there are several (say more than 4) contributors. Recently methods have been propo...

متن کامل

Bounding the number of contributors to mixed DNA stains.

We derive a simple inequality for the probability of observing a given DNA profile when assuming a fixed number of unknown persons have contributed to the mixed stain. We then show how this inequality can be used to obtain an upper bound for the number of unknown contributors needed to be considered.

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013